About
Prof. Misra is an internationally acclaimed researcher and scientist. He has been a member of a number of National and International policy and decision-making bodies in internal medicine, diabetes, obesity and cardiovascular diseases. He has been a member of WHO and ICMR Expert Groups for Childhood Obesity (2005, 2006), WHO Expert Committee for Appropriate Measures of Obesity in Asian Populations (2005), and ICMR Expert Committee on Fatty Liver (2007). He has been a key member for National Control Programs for Diabetes and Cardiovascular Disease, India, Founding member, Diabetes in Asia Group, and in various top-level national committees set up by Health Ministry, Planning Commission, Indian Council of Medical Research, Dept. of Biotechnology, Department of Science and Technology, and the World Health Organization. He and is in monitoring committees for National Institute of Nutrition (Hyderabad) and National Nutrition Monitoring Bureau. He has been in Health Ministry committees for developing national guidelines in drugs and pharmaceuticals, and is a member of National Pharmacovigilance Committee, Indian Pharmacopoeia and Department of Biotechnology. He is Chief Scientific Advisor, Diabetes Foundation (India), and core committee member of Diabetes India. He is Chairman, Scientific Advisory Board, Chronic Care Foundation, India. He is Secretary, Treasurer and Steering Committee member of prestigious Magnuson's Global Diabetes Research Alliance Group (2008).
Unique Contribution
Prof. Misra has published more than 250 scientific papers in the international journals. He has received several prestigious orations and awards including and abroad: S.N. Tripathy Memorial Oration (2003), Prof. Austin E. Doyle Oration (2004), Dr K.L. Wig Oration (2005), Sam G. Moses Oration (2005), Prof. B.R. Sengupta Oration (2005), Searle Oration (2006), and Amar Sen Oration (2006), DK Pal Chowdhary Oration (2006), Dr OP Gupta Oration (2007) and prestigious Kamala Puri Sabharwal Oration (2007). He has been awarded highest award for medicine in India Dr BC Roy award (2006) and prestigious National Honour, Padma Shree (2007).
He has several important new scientific findings to his credit including new definitions of obesity, abdominal obesity and syndrome X in Asian Indians and new test for monitoring of diabetes. He has several research projects (hypothesis driven, genetic-metabolic, clinical pharmacology research etc) involving several collaborators in India and in other countries (USA, UK, The Netherlands, Australia etc).
He is in editorial boards of seven international journals including:
International Journal of Obesity (USA)
Nutrition, Metabolism, and Cardiovascular Diseases (Italy)
Metabolic Syndrome and Related Disorders (USA)
Diabetes Research and Clinical Practice (UK)
International Diabetes Monitor (Sweden)
Medical Science Monitor (USA)
Journal of Diabetes in Asia Group
Associate Editor of "Diabetes and Metabolic Syndrome; Research and Reviews (Singapore).
He is also one of the editors of "Year Book of Diabetes, 2007". He is reviewer for several prestigious international journals including ‘The Lancet'. ‘Journal of Clinical Endocrinology and Metabolism' and ‘Circulation". He is member of Elsevier Scientific Advisory Board on Diabetes in India.
He has served as Personal Physician to two former Prime Ministers of India.
Prof. Misra has conducted several large-scale community outreach programs for children, women and underprivileged. He has started the biggest health education programs for school children in Asia aiming at prevention of obesity and diabetes and for healthy nutrition now covering 500,000 children in 10 cities in north India, aided by grant from World Diabetes Foundation, Denmark (Project "MARG").
The focus of Dr. Misra's research has been on obesity, metabolic syndrome (syndrome X), diabetes mellitus, hyperlipidemia and other cardiovascular risk factors in Asian Indians and rare disorders of adipose tissue.
For the first time, Dr. Misra's team showed a high prevalence of Type 2 Diabetes Mellitus, abdominal obesity, dyslipidemia and metabolic syndrome in the underprivileged population living in urban resettlement colonies of New Delhi. Other previously unreported observations on the same population included a high prevalence of hyperhomocysteinemia, endothelial dysfunction and subclinical inflammation. His team also carried out epidemiological study of metabolic syndrome and cardiovascular risk factors of post-menopausal women belonging to low socio-economic stratum, and reported a marked clustering of cardiovascular risk factors. His team's health awareness program in poor socio-economic stratum is based on the above findings.
Dr. Misra and his team have reported markedly imbalanced nutrition among the underprivileged; high total and saturated fat, low intakes of fibre and ω-3 fatty acids, and low intakes of anti-oxidants in the people belonging to low socio-economic stratum in urban slums.
In serial studies, Dr. Misra and his team recorded a rising prevalence of obesity among schoolchildren in Delhi. They have also reported a high intake of energy-dense food and carbonated beverages in children, resulting in a high prevalence of insulin resistance among them, which correlates to the intake of n-6 fatty acids. Other important findings include a high intake of saturated fat and trans fatty acids.
Based on high levels of C-reactive protein in children, Dr. Misra calculated that saturated fat intake in adolescents should be restricted to <7%. In a preliminary communication, they reported that ~ 65% of adolescent and young population in schools and colleges of New Delhi are sedentary.
This important study, carried out for the first time, aimed to assess the obesity, insulin resistance, diabetes, and other cardiovascular risk factors in Asian Indians at three sites: USA, urban and rural India. The study shows a stepwise increase in the prevalence of diabetes and cardiovascular risk factors in rural and urban populations in India, and migrant Asian Indians at 6 sites in USA. The study also highlights the high prevalence of abdominal obesity and metabolic syndrome in Asian Indians. An important finding is the rising prevalence of diabetes and obesity in rural populations as well.
This study, done on four urban and four rural centers in India, shows high prevalence of diabetes, hypertension, obesity and dyslipidemia in women 35 years of age, in addition of highly imbalanced dietary profile.
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